Gut-liver crosstalk in sepsis-induced liver injury
نویسندگان
چکیده
منابع مشابه
Ethanol modulates gut ischemia/reperfusion-induced liver injury in rats.
Whereas both ethanol and gut ischemia/reperfusion (I/R) are known to alter hepatic microvascular function, little is known about the influence of ethanol consumption on the hepatic microvascular responses to I/R. The objective of this study was to determine whether acute ethanol administration exacerbates the hepatic microvascular dysfunction induced by gut I/R. Rats were exposed to gut ischemi...
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The gastrointestinal tract has various functions including digestion, the production of hormones with local and systemic effects, a major role in immunological function, and acting as a barrier against antigens within its lumen. The intestinal microflora is an ecosystem which harbours over 400 bacterial species, predominantly anaerobes which outnumber facultative anaerobes. Most flora is presen...
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The functions of the liver are very diverse. From detoxifying blood to storing glucose in the form of glycogen and producing bile to facilitate fat digestion, the liver is a very active and important organ. The liver is comprised of many varied cell types whose functions are equally diverse. Cholangiocytes line the biliary tree and aid in transporting and adjusting the composition of bile as it...
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A capability for analyzing complex cellular communication among tissues is important in drug discovery and development, and in vitro technologies for doing so are required for human applications. A prominent instance is communication between the gut and the liver, whereby perturbations of one tissue can influence behavior of the other. Here, we present a study on human gut-liver tissue interact...
متن کاملLamivudine-Induced Liver Injury
BACKGROUND Lamivudine is a nucleoside analogue antiretroviral drug, known for its low toxicity at clinically prescribed dose. However, the toxicity or mechanism of toxicity and target tissue effects during prolonged administration of higher doses were hardly given sufficient laboratory attention. AIM The present work was designed to investigate the biochemical and histopathological changes in...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2020
ISSN: 1364-8535
DOI: 10.1186/s13054-020-03327-1